The Panthers had been pointing to the opener from the moment the program announced the move from the Big East to the ACC nearly two years ago. Playing in front of a rare sell-out, Pitt simply couldn't keep up with the defending league champions.
Tom Savage passed for 201 yards and a touchdown for Pitt but also threw a pair of interceptions.
Or, as many interceptions as Winston had incompletions.
Winston won the starting job during training camp, edging out Jacob Coker to become just the third freshman to start a season opener for the Seminoles.
Don't plan on him giving up the gig anytime soon.
A star outfielder on the school baseball team, Winston is considered the latest in a line of two-sport threats at Florida State, a list that includes Pro Football Hall of Famer Deion Sanders and 1992 Heisman Trophy winner Charlie Ward.
Ward, however, didn't become a star until he finally cracked the starting lineup as a junior. Winston appears to already be there a game into his career.
Winston connected on his first 11 passes, missing on his 12th when wide receiver Kenny Shaw couldn't quite get his right foot all the way inbounds.
The 6-foot-4, 227-pound kid from Hueytown, Ala., nicknamed ``Famous Jameis'' did a little bit of everything. Twice he pulled himself free from a defensive lineman's grasp to find a receiver downfield. He converted a first-and-28 with a 36-yard strike to Greene and even served as the lead blocker for Devonta Freeman when the running back broke into the secondary.
Pitt's defense, which ranked 17th in the country last season, appeared unsure on how to stop him. Wary of the speed of Florida State's wide receivers, the Panthers gave Greene and company plenty of room to maneuver.
Too much, as it turned out. Way too much. For all of Winston's precision, often he was throwing to teammates who didn't have anybody in dressed in blue within arm's reach.
The Panthers were primed early looking to prove they belonged in the better, deeper ACC after more than two decades of middling success in the crumbling Big East.
If Savage was nervous about kick-starting a collegiate career that was on life support for more than two years, it didn't show. The quarterback who led Rutgers to a 12-1 record as a freshman in 2009 hit Devin Street for a 31-yard gain on Pitt's first drive, Savage's first completion in a game in 1,024 days.
For a few minutes, the 23-year-old appeared in a hurry to make up for lost time.
He hit Street again for 16 yards before finding Manasseh Garner for a 4-yard touchdown to give Pitt a quick 7-0 lead. The toss completed a full career arc for the well-traveled Savage, who transferred to Arizona in 2011 before moving on to Pitt last year. His previous touchdown pass came on Oct. 23, 2010, while playing mop-up duty for the Scarlet Knights in a 41-21 loss to the Panthers.
It was a nice moment, but all it did was set the stage for Winston.
Florida State's first drive fizzled. The second ended with Winston hitting O'Leary -- the grandson of golfing great Jack Nicklaus -- for a 24-yard touchdown. The two hooked up again on the next drive, with Winston executing a perfect play fake before flipping the ball to O'Leary in the back of the end zone to give Florida State a 14-10 lead.
Pitt responded with a field goal to draw within four by the Seminoles were just getting started. Winston ended a 14-play, 78-yard march with a 5-yard touchdown run in which he bulled through a Panther defender before crossing the goal line to make it 21-10 with 2:13 left in the first half.
Savage threw an interception on Pitt's ensuing possession and Winston needed all of three plays to put things out of reach. When an illegal block and a delay of game had the Seminoles facing first-and-28, he found Greene down the sideline with a perfect throw to Greene's back shoulder. On the next snap Winston found Greene over the middle for a score to put the Seminoles up 28-10.