The roadway was closed in both directions between Yates Road and Cunningham Road in Young Township.
The crash happened just before two o'clock on Monday afternoon.
There are reports that diesel fuel and coal debris were covering the road.
There's no word on what caused the crash.
The condition of the drivers is unknown.
Copyright 2015 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.