Documents filed in federal court accuse Fedex of enabling criminal activity.
The indictment accuses Fedex of shipping prescription drugs from illegal online pharmacies to addicts and to drug dealers.
A spokesman for the company says Fedex is innocent of any wrongdoing.
The spokesman says Fedex is willing to assist law enforcement but can't do the job of law enforcement alone.
Prosecutors say the charges are the result of a nine year investigation into two internet pharmacies.
A conviction could mean more than $820 million in fines and penalties against Fedex.
Copyright 2015 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.